|
KMID : 0941820090190010065
|
|
Korean Journal of Clinical Pharmacy
2009 Volume.19 No. 1 p.65 ~ p.68
|
|
|
Determination of Flow Rate and Stability of 5-Fluorouracil in Disposal Infusion Device, Anapa
|
|
Kim Jung-Tae
Chung Sung-Hyun
|
|
|
Abstract
|
|
|
|
Disposal infusion device is known to be useful for chemotherapy. Anti-cancer drug can be released by the force of carbon dioxide or balloon. In this study, we compared the Anapa® (LC0020) with B Company (LV2 ml) in terms of infusion rate and stability. Infusion rate was determined every six minute using software, MSI08IH. Stability of 5-fluorouracil was examined periodically using a High Performance Liquid Chromatography. Infusion rates of gas-derived Anapa device were 2.29, 1.86, 1.98 ml/hr and those of balloon-derived B Company device were 1.71, 1.58, 1.37 ml/ min. There were no significant differences in stability of 5-fluorouracil between Anapa® and B Company devices. In summary, gas-derived Anapa® device is thought to be comparable or superior to balloon-derived B Company device as far as infusion rate and stability are concerned. We expect that Anapa® as a home infusion device can be employed to improve a quality of life and compliance of cancer patients.
|
|
|
KEYWORD
|
|
|
Infusion, Anapa®, Flow rate, Stability, 5-fluorouracil
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|